Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15

A variety of CTX-M-type extended-spectrum β-lactamases (ESBLs), including hybrid ones, have been reported in China that are uncommon elsewhere. To better characterize the substrate profiles and enzymatic mechanisms of these enzymes, we performed comparative kinetic analyses of both parental and hybr...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: He, Dandan, Chiou, Jiachi, Zeng, Zhenling, Liu, Lanping, Chen, Xiaojie, Zeng, Li, Chan, Edward Wai Chi, Liu, Jian-Hua, Chen, Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576060/
https://ncbi.nlm.nih.gov/pubmed/26169409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04920-14
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