Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15

A variety of CTX-M-type extended-spectrum β-lactamases (ESBLs), including hybrid ones, have been reported in China that are uncommon elsewhere. To better characterize the substrate profiles and enzymatic mechanisms of these enzymes, we performed comparative kinetic analyses of both parental and hybr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: He, Dandan, Chiou, Jiachi, Zeng, Zhenling, Liu, Lanping, Chen, Xiaojie, Zeng, Li, Chan, Edward Wai Chi, Liu, Jian-Hua, Chen, Sheng
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Mechanisms of Resistance
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576060/
https://ncbi.nlm.nih.gov/pubmed/26169409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04920-14
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