8-Hydroxyquinolines Are Boosting Agents of Copper-Related Toxicity in Mycobacterium tuberculosis

Copper (Cu) ions are likely the most important immunological metal-related toxin utilized in controlling bacterial infections. Impairment of bacterial Cu resistance reduces viability within the host. Thus, pharmacological enhancement of Cu-mediated antibacterial toxicity may lead to novel strategies...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Shah, Santosh, Dalecki, Alex G., Malalasekera, Aruni P., Crawford, Cameron L., Michalek, Suzanne M., Kutsch, Olaf, Sun, Jim, Bossmann, Stefan H., Wolschendorf, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038248/
https://ncbi.nlm.nih.gov/pubmed/27431227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00325-16
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