Copper-Boosting Compounds: a Novel Concept for Antimycobacterial Drug Discovery

We and others recently identified copper resistance as important for virulence of Mycobacterium tuberculosis. Here, we introduce a high-throughput screening assay for agents that induce a copper hypersensitivity phenotype in M. tuberculosis and demonstrate that such copper-boosting compounds are eff...

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Main Authors: Speer, Alexander, Shrestha, Tej B., Bossmann, Stefan H., Basaraba, Randall J., Harber, Gregory J., Michalek, Suzanne M., Niederweis, Michael, Kutsch, Olaf, Wolschendorf, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Susceptibility
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553712/
https://ncbi.nlm.nih.gov/pubmed/23254420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01781-12
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