Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

Bacterial aminoacyl-tRNA synthetases (aaRSs) represent promising antibacterial drug targets. Unfortunately, the aaRS inhibitors that have to date reached clinical trials are subject to rapid resistance development through mutation, a phenomenon that limits their potential clinical utility. Here, we...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Randall, Christopher P., Rasina, Dace, Jirgensons, Aigars, O'Neill, Alex J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038231/
https://ncbi.nlm.nih.gov/pubmed/27431224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00674-16
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