A Coccidioides posadasii CPS1 Deletion Mutant Is Avirulent and Protects Mice from Lethal Infection

The CPS1 gene was identified as a virulence factor in the maize pathogen Cochliobolus heterostrophus. Hypothesizing that the homologous gene in Coccidioides posadasii could be important for virulence, we created a Δcps1 deletion mutant which was unable to cause disease in three strains of mice (C57B...

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Опубликовано в: :Infect Immun
Главные авторы: Narra, Hema P., Shubitz, Lisa F., Mandel, M. Alejandra, Trinh, Hien T., Griffin, Kurt, Buntzman, Adam S., Frelinger, Jeffrey A., Galgiani, John N., Orbach, Marc J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Molecular Pathogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038059/
https://ncbi.nlm.nih.gov/pubmed/27481239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00633-16
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