HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix

Chondroitin sulfate (CS) glycosaminoglycans inhibit regeneration in the adult central nervous system (CNS). We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Paveliev, Mikhail, Fenrich, Keith K., Kislin, Mikhail, Kuja-Panula, Juha, Kulesskiy, Evgeny, Varjosalo, Markku, Kajander, Tommi, Mugantseva, Ekaterina, Ahonen-Bishopp, Anni, Khiroug, Leonard, Kulesskaya, Natalia, Rougon, Geneviève, Rauvala, Heikki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037378/
https://ncbi.nlm.nih.gov/pubmed/27671118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33916
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