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Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein
The protein alpha-synuclein (αS) self-assembles into toxic beta-sheet aggregates in Parkinson’s disease, while it is proposed that αS forms soluble alpha-helical multimers in healthy neurons. Here, we have made αS multimers in vitro using arachidonic acid (ARA), one of the most abundant fatty acids...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5037366/ https://ncbi.nlm.nih.gov/pubmed/27671749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33928 |
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