TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway

The tuberous sclerosis complex 1 (TSC1) is a tumor suppressor that inhibits the mammalian target of rapamycin (mTOR), which serves as a key regulator of inflammatory responses after bacterial stimulation in monocytes, macrophages, and primary dendritic cells. Previous studies have shown that TSC1 kn...

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Publicado en:Cell Mol Immunol
Autores principales: Yang, Tao, Zhu, Linnan, Zhai, Yanhua, Zhao, Qingjie, Peng, Jianxia, Zhang, Hongbing, Yang, Zhongzhou, Zhang, Lianfeng, Ding, Wenjun, Zhao, Yong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037279/
https://ncbi.nlm.nih.gov/pubmed/27593484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.43
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