Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

BACKGROUND & AIMS: There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of non-alcoholic steatohepatitis (NASH), but the exact mechanisms are not clear. Mice with disruption of the gene (F11r) encoding junctional adhesion mole...

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Vydáno v:Gastroenterology
Hlavní autoři: Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S., Thorn, Natalie E., Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S., Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B., Nusrat, Asma, Parkos, Charles A., Anania, Frank A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037035/
https://ncbi.nlm.nih.gov/pubmed/27342212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2016.06.022
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