Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases

INTRODUCTION: Optimal approaches to induce T cell infiltration of tumors are not known. Chemokines CXCL9, CXCL10, and CXCL11 support effector T cell recruitment and may be induced by IFN. This study tests the hypothesis that intratumoral administration of IFNγ will induce CXCL9–11 and will induce T...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Mauldin, Ileana S., Wages, Nolan A., Stowman, Anne M., Wang, Ena, Smolkin, Mark E., Olson, Walter C., Deacon, Donna H., Smith, Kelly T., Galeassi, Nadedja V., Chianese‐Bullock, Kimberly A., Dengel, Lynn T., Marincola, Francesco M., Petroni, Gina R., Mullins, David W., Slingluff, Craig L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5037033/
https://ncbi.nlm.nih.gov/pubmed/27522581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1881-y
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