Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34(+) and more mature CD34(−) AML have heterogeneous immunophenotypes overlapping with normal stem/progenitor cells (SPC) b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Khan, Naeem, Hills, Robert K., Knapper, Steve, Steadman, Lora, Qureshi, Ushna, Rector, Jerrald L., Bradbury, Charlotte, Russell, Nigel H., Vyas, Paresh, Burnett, Alan K., Grimwade, David, Hole, Paul S., Freeman, Sylvie D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036879/
https://ncbi.nlm.nih.gov/pubmed/27669008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163291
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