The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias

Tefinostat (CHR-2845) is a novel monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor which is cleaved into its active acid by the intracellular esterase human carboxylesterase-1 (hCE-1). The in vitro efficacy of tefinostat was characterised in cell lines and in a cohort of 73 primary A...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zabkiewicz, Joanna, Gilmour, Marie, Hills, Robert, Vyas, Pares, Bone, Elizabeth, Davidson, Alan, Burnett, Alan, Knapper, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941341/
https://ncbi.nlm.nih.gov/pubmed/26934551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7692
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