Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

Various genetic mutations associated with cancer are known to alter cell signaling, but it is not clear whether they dysregulate signaling pathways by altering the abundance of pathway proteins. Using a combination of RNA sequencing and ultrasensitive targeted proteomics, we defined the primary comp...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Shi, Tujin, Niepel, Mario, McDermott, Jason E., Gao, Yuqian, Nicora, Carrie D., Chrisler, William B., Markillie, Lye M., Petyuk, Vladislav A., Smith, Richard D., Rodland, Karin D., Sorger, Peter K., Qian, Wei-Jun, Wiley, H. Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036860/
https://ncbi.nlm.nih.gov/pubmed/27405981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf0891
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