Sensitive Targeted Quantification of ERK Phosphorylation Dynamics and Stoichiometry in Human Cells without Affinity Enrichment

[Image: see text] Targeted mass spectrometry is a promising technology for site-specific quantification of posttranslational modifications. However, a major constraint is the limited sensitivity for quantifying low-abundance PTMs, requiring the use of affinity reagents for enrichment. Herein, we dem...

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Vydáno v:Anal Chem
Hlavní autoři: Shi, Tujin, Gao, Yuqian, Gaffrey, Matthew J., Nicora, Carrie D., Fillmore, Thomas L., Chrisler, William B., Gritsenko, Marina A., Wu, Chaochao, He, Jintang, Bloodsworth, Kent J., Zhao, Rui, Camp, David G., Liu, Tao, Rodland, Karin D., Smith, Richard D., Wiley, H. Steven, Qian, Wei-Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365449/
https://ncbi.nlm.nih.gov/pubmed/25517423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac503797x
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