The Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease

Alexander disease (AxD) is a neurodegenerative disorder characterized by astrocytic protein aggregates called Rosenthal fibers (RFs). We used mouse models of AxD to determine the protein composition of RFs to obtain information about disease mechanisms, including the hypothesis that sequestration of...

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Veröffentlicht in:J Proteome Res
Hauptverfasser: Heaven, Michael R., Flint, Daniel, Randall, Shan M., Sosunov, Alexander A., Wilson, Landon, Barnes, Stephen, Goldman, James E., Muddiman, David C., Brenner, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036859/
https://ncbi.nlm.nih.gov/pubmed/27193225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00316
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