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The Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease

Alexander disease (AxD) is a neurodegenerative disorder characterized by astrocytic protein aggregates called Rosenthal fibers (RFs). We used mouse models of AxD to determine the protein composition of RFs to obtain information about disease mechanisms, including the hypothesis that sequestration of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Proteome Res
Egile Nagusiak: Heaven, Michael R., Flint, Daniel, Randall, Shan M., Sosunov, Alexander A., Wilson, Landon, Barnes, Stephen, Goldman, James E., Muddiman, David C., Brenner, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036859/
https://ncbi.nlm.nih.gov/pubmed/27193225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00316
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