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Inhibiting mitochondrial DNA ligase IIIα activates caspase 1-dependent apoptosis in cancer cells
Elevated levels of DNA ligase IIIα (LigIIIα) have been identified as a biomarker of an alteration in DNA repair in cancer cells that confers hypersensitivity to a LigIIIα inhibitor, L67, in combination with a poly (ADP-ribose) polymerase inhibitor. Since LigIIIα functions in the nucleus and mitochon...
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| Gepubliceerd in: | Cancer Res |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036517/ https://ncbi.nlm.nih.gov/pubmed/27503931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3243 |
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