In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome

OBJECTIVE: Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the a...

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Bibliographische Detailangaben
Veröffentlicht in:Gut
Hauptverfasser: Todt, Daniel, Gisa, Anett, Radonic, Aleksandar, Nitsche, Andreas, Behrendt, Patrick, Suneetha, Pothakamuri Venkata, Pischke, Sven, Bremer, Birgit, Brown, Richard J P, Manns, Michael P, Cornberg, Markus, Bock, C Thomas, Steinmann, Eike, Wedemeyer, Heiner
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2016
Schlagworte:
Hepatology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036239/
https://ncbi.nlm.nih.gov/pubmed/27222534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-311000
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