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In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome

OBJECTIVE: Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the a...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Todt, Daniel, Gisa, Anett, Radonic, Aleksandar, Nitsche, Andreas, Behrendt, Patrick, Suneetha, Pothakamuri Venkata, Pischke, Sven, Bremer, Birgit, Brown, Richard J P, Manns, Michael P, Cornberg, Markus, Bock, C Thomas, Steinmann, Eike, Wedemeyer, Heiner
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036239/
https://ncbi.nlm.nih.gov/pubmed/27222534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-311000
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