Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing palmitoyl acyltransferases (PATs) in mediating endothelial inflammation. Pharmacological inhibition of PATs attenuates barrier leakage and leu...

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Publicat a:Nat Commun
Autors principals: Beard, Richard S., Yang, Xiaoyuan, Meegan, Jamie E., Overstreet, Jonathan W., Yang, Clement G.Y., Elliott, John A., Reynolds, Jason J., Cha, Byeong J., Pivetti, Christopher D., Mitchell, David A., Wu, Mack H., Deschenes, Robert J., Yuan, Sarah Y.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036164/
https://ncbi.nlm.nih.gov/pubmed/27653213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12823
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