An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear. Here, we use targeted mass spectrometry to identify specialized pro-resolving lipid mediators (SPM) in histologically-defi...

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Publicat a:Nat Commun
Autors principals: Fredman, Gabrielle, Hellmann, Jason, Proto, Jonathan D., Kuriakose, George, Colas, Romain A., Dorweiler, Bernhard, Connolly, E. Sander, Solomon, Robert, Jones, David M., Heyer, Eric J., Spite, Matthew, Tabas, Ira
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036151/
https://ncbi.nlm.nih.gov/pubmed/27659679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12859
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