Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4

The mannose receptor (MR) is an endocytic receptor involved in serum homeostasis and antigen presentation. Here, we identify the MR as a direct regulator of CD8(+) T-cell activity. We demonstrate that MR expression on dendritic cells (DCs) impaired T-cell cytotoxicity in vitro and in vivo. This regu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schuette, Verena, Embgenbroich, Maria, Ulas, Thomas, Welz, Meike, Schulte-Schrepping, Jonas, Draffehn, Astrid M., Quast, Thomas, Koch, Katharina, Nehring, Melanie, König, Jessica, Zweynert, Annegret, Harms, Frederike L., Steiner, Nancy, Limmer, Andreas, Förster, Irmgard, Berberich-Siebelt, Friederike, Knolle, Percy A., Wohlleber, Dirk, Kolanus, Waldemar, Beyer, Marc, Schultze, Joachim L., Burgdorf, Sven
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035904/
https://ncbi.nlm.nih.gov/pubmed/27601670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605885113
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