Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung

Pulmonary sclerosing hemangioma (PSH) is a benign tumor with two cell populations (epithelial and stromal cells), for which genomic profiles remain unknown. We conducted exome sequencing of 44 PSHs and identified recurrent somatic mutations of AKT1 (43.2%) and β-catenin (4.5%). We used a second subs...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Jung, Seung-Hyun, Kim, Min Sung, Lee, Sung-Hak, Park, Hyun-Chun, Choi, Hyun Joo, Maeng, Leeso, Min, Ki Ouk, Kim, Jeana, Park, Tae In, Shin, Ok Ran, Kim, Tae-Jung, Xu, Haidong, Lee, Kyo Young, Kim, Tae-Min, Song, Sang Yong, Lee, Charles, Chung, Yeun-Jun, Lee, Sug Hyung
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035874/
https://ncbi.nlm.nih.gov/pubmed/27601661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606946113
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