Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung

Pulmonary sclerosing hemangioma (PSH) is a benign tumor with two cell populations (epithelial and stromal cells), for which genomic profiles remain unknown. We conducted exome sequencing of 44 PSHs and identified recurrent somatic mutations of AKT1 (43.2%) and β-catenin (4.5%). We used a second subs...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jung, Seung-Hyun, Kim, Min Sung, Lee, Sung-Hak, Park, Hyun-Chun, Choi, Hyun Joo, Maeng, Leeso, Min, Ki Ouk, Kim, Jeana, Park, Tae In, Shin, Ok Ran, Kim, Tae-Jung, Xu, Haidong, Lee, Kyo Young, Kim, Tae-Min, Song, Sang Yong, Lee, Charles, Chung, Yeun-Jun, Lee, Sug Hyung
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035874/
https://ncbi.nlm.nih.gov/pubmed/27601661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606946113
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