Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non–Small-Cell Lung Cancer

PURPOSE: Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated potent activity against TKI resistance mediated by EGFR T790M. We studied whether noninvasive genotyping of cell-free plasma DNA (cfDNA) is a useful biomarker for prediction of outco...

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Pubblicato in:J Clin Oncol
Autori principali: Oxnard, Geoffrey R., Thress, Kenneth S., Alden, Ryan S., Lawrance, Rachael, Paweletz, Cloud P., Cantarini, Mireille, Yang, James Chih-Hsin, Barrett, J. Carl, Jänne, Pasi A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2016
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035123/
https://ncbi.nlm.nih.gov/pubmed/27354477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.66.7162
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