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Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock

Excessive inflammatory and oxidative stress lead to circulatory failure, multiple organ dysfunction, and high mortality in patients with sepsis. Microbial infection-induced DNA hypermethylation is associated with the augmentation of inflammation and oxidative stress. In our previous study, the antia...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Shih, Chih-Chin, Liao, Mei-Hui, Hsiao, Tsan-Seng, Hii, Hiong-Ping, Shen, Ching-Hui, Chen, Shiu-Jen, Ka, Shuk-Man, Chang, Yung-Lung, Wu, Chin-Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035080/
https://ncbi.nlm.nih.gov/pubmed/27661616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163690
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