Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock

Excessive inflammatory and oxidative stress lead to circulatory failure, multiple organ dysfunction, and high mortality in patients with sepsis. Microbial infection-induced DNA hypermethylation is associated with the augmentation of inflammation and oxidative stress. In our previous study, the antia...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Shih, Chih-Chin, Liao, Mei-Hui, Hsiao, Tsan-Seng, Hii, Hiong-Ping, Shen, Ching-Hui, Chen, Shiu-Jen, Ka, Shuk-Man, Chang, Yung-Lung, Wu, Chin-Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035080/
https://ncbi.nlm.nih.gov/pubmed/27661616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163690
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