Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors

BACKGROUND: Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Fiv...

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Vydáno v:PLoS One
Hlavní autoři: Nelveg-Kristensen, Karl Emil, Bie, Peter, Ferrero, Laura, Bjerre, Ditte, Bruun, Niels E., Egfjord, Martin, Rasmussen, Henrik B., Hansen, Peter R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035013/
https://ncbi.nlm.nih.gov/pubmed/27662362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163341
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