Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors.

BACKGROUND:Variation in the carboxylesterase 1 gene (CES1) may contribute to the efficacy of ACEIs. Accordingly, we examined the impact of CES1 variants on plasma angiotensin II (ATII)/angiotensin I (ATI) ratio in patients with congestive heart failure (CHF) that underwent ACEI dose titrations. Five...

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Detalhes bibliográficos
Main Authors: Karl Emil Nelveg-Kristensen, Peter Bie, Laura Ferrero, Ditte Bjerre, Niels E Bruun, Martin Egfjord, Henrik B Rasmussen, Peter R Hansen, INDICES Consortium
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC5035013?pdf=render
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