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Per2-Mediated Vascular Dysfunction Is Caused by the Upregulation of the Connective Tissue Growth Factor (CTGF)
Period 2-mutant mice (Per2(m/m)), which possess a circadian dysfunction, recapitulate the retinal vascular phenotype similar to diabetic retinopathy (DR). The vascular dysfunction in Per2(m/m) is associated with an increase in connective tissue growth factor (CTGF/CCN2). At the molecular level, CTGF...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035004/ https://ncbi.nlm.nih.gov/pubmed/27662578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163367 |
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