Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration

Calcineurin inhibitors such as cyclosporine A (CsA) are still commonly used after renal transplantation, despite CsA–induced nephrotoxicity (CIN), which is partly related to vasoactive mechanisms. The mineralocorticoid receptor (MR) is now recognized as a key player in the control of vascular tone,...

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Gepubliceerd in:Kidney Int
Hoofdauteurs: Amador, Cristian A., Bertocchio, Jean-Philippe, Andre-Gregoire, Gwennan, Placier, Sandrine, Van Huyen, Jean-Paul Duong, El Moghrabi, Soumaya, Berger, Stefan, Warnock, David G., Chatziantoniou, Christos, Jaffe, Iris Z., Rieu, Philippe, Jaisser, Frederic
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034861/
https://ncbi.nlm.nih.gov/pubmed/26422501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.312
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