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Evaluation of CYP3A‐mediated drug–drug interactions with romidepsin in patients with advanced cancer
Two multicenter, single‐arm, single‐infusion, open‐label studies were conducted to evaluate the effect of ketoconazole (a strong CYP3A inhibitor) or rifampin (a strong CYP3A inducer) daily for 5 days on the pharmacokinetics (PK) and safety of romidepsin (8 mg/m(2) intravenous 4‐hour infusion for the...
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| Publicado no: | J Clin Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034805/ https://ncbi.nlm.nih.gov/pubmed/26053962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.560 |
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