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Ginsenoside Rg3, a Gating Modifier of EAG Family K(+) Channels

Ginsenoside 20(S)-Rg3 (Rg3) is a steroid glycoside that induces human ether-à-go-go-related gene type 1 (hERG1, Kv11.1) channels to activate at more negative potentials and to deactivate more slowly than normal. However, it is unknown whether this action is unique to hERG1 channels. Here we compare...

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Détails bibliographiques
Publié dans:Mol Pharmacol
Auteurs principaux: Wu, Wei, Gardner, Alison, Sachse, Frank B., Sanguinetti, Michael C.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034692/
https://ncbi.nlm.nih.gov/pubmed/27502018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.104091
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