In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia

BACKGROUND: Teriflunomide, an inhibitor of dihydroorotate dehydrogenase, is thought to ameliorate multiple sclerosis by reducing activation-induced proliferation of lymphocytes, which is highly dependent on de novo pyrimidine synthesis. Nevertheless, its immunomodulatory effects on resident glial ce...

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Publicado en:J Neuroinflammation
Autores principales: Wostradowski, Tanja, Prajeeth, Chittappen Kandiyil, Gudi, Viktoria, Kronenberg, Jessica, Witte, Sina, Brieskorn, Marina, Stangel, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034581/
https://ncbi.nlm.nih.gov/pubmed/27658519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0715-3
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