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Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

OBJECTIVE: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Mera, Paula, Laue, Kathrin, Wei, Jianwen, Berger, Julian Meyer, Karsenty, Gerard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034485/
https://ncbi.nlm.nih.gov/pubmed/27689017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.07.002
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