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Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

OBJECTIVE: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice...

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Publicado en:Mol Metab
Main Authors: Mera, Paula, Laue, Kathrin, Wei, Jianwen, Berger, Julian Meyer, Karsenty, Gerard
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034485/
https://ncbi.nlm.nih.gov/pubmed/27689017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.07.002
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