Downregulation of angiotensin type 1 receptor and nuclear factor-κB by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction

Activation of sirtuin 1 (Sirt1) attenuates unilateral ureteral obstruction (UUO)-induced inflammation and fibrosis, suggesting that Sirt1 may prevent tubulointerstitial fibrosis. In this study, we explored changes in the expression of Sirt1 in the kidneys of UUO-treated rats and evaluated the effect...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yang, Shao-Yu, Lin, Shuei-Liong, Chen, Yung-Ming, Wu, Vin-Cent, Yang, Wei-Shiung, Wu, Kwan-Dun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034227/
https://ncbi.nlm.nih.gov/pubmed/27659793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33705
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