A Targeted Mutation Identified through pK(a) Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission

The tail-anchored protein Fis1 is implicated as a passive tether in yeast mitochondrial fission. We probed the functional role of Fis1 Glu-78, whose elevated side chain pK(a) suggests participation in protein interactions. Fis1 binds partners Mdv1 or Dnm1 tightly, but mutation E78A weakens Fis1 inte...

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Foilsithe in:J Biol Chem
Main Authors: Koppenol-Raab, Marijke, Harwig, Megan Cleland, Posey, Ammon E., Egner, John M., MacKenzie, Kevin R., Hill, R. Blake
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034033/
https://ncbi.nlm.nih.gov/pubmed/27496949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724005
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