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Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain
Adeno-associated viruses (AAV) are currently being evaluated in clinical trials for gene therapy of CNS disorders. However, host factors that influence the spread, clearance, and transduction efficiency of AAV vectors in the brain are not well understood. Recent studies have demonstrated that fluid...
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| Publicat a: | JCI Insight |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033923/ https://ncbi.nlm.nih.gov/pubmed/27699236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88034 |
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