A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti–IL-6R treatment

Transgenic expression of key myelosupportive human cytokines in immune-deficient mice corrects for the lack of cross-species activities of stem cell factor (SCF), IL-3, and GM-CSF. When engrafted with human umbilical cord blood (UCB), these triple-transgenic mice produce BM and spleen grafts with mu...

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Pubblicato in:JCI Insight
Autori principali: Wunderlich, Mark, Stockman, Courtney, Devarajan, Mahima, Ravishankar, Navin, Sexton, Christina, Kumar, Ashish R., Mizukawa, Benjamin, Mulloy, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033750/
https://ncbi.nlm.nih.gov/pubmed/27699249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88181
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