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Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development

B cell development is often depicted as a linear process initiating in the fetus and continuing postnatally. Using a PU.1 hypomorphic mouse model, we found that B-1 and B-2 lymphopoiesis occurred in distinct fetal and adult waves differentially dependent on the Sfpi1 14 kB upstream regulatory elemen...

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Publicat a:Immunity
Autors principals: Montecino-Rodriguez, Encarnacion, Fice, Michael, Casero, David, Berent-Maoz, Beata, Barber, Chad L., Dorshkind, Kenneth
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033716/
https://ncbi.nlm.nih.gov/pubmed/27566938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.012
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