IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

IRS-1 is an insulin receptor substrate that undergoes tyrosine phosphorylation and associates with the phosphatidylinositol (PtdIns) 3'-kinase immediately after insulin stimulation. Recombinant IRS-1 protein was tyrosine phosphorylated by the insulin receptor in vitro and associated with the PtdIns...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Myers, M G, Backer, J M, Sun, X J, Shoelson, S, Hu, P, Schlessinger, J, Yoakim, M, Schaffhausen, B, White, M F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1332046/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10350
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