IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

IRS-1 is an insulin receptor substrate that undergoes tyrosine phosphorylation and associates with the phosphatidylinositol (PtdIns) 3'-kinase immediately after insulin stimulation. Recombinant IRS-1 protein was tyrosine phosphorylated by the insulin receptor in vitro and associated with the Pt...

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Hlavní autoři: Myers, M G, Backer, J M, Sun, X J, Shoelson, S, Hu, P, Schlessinger, J, Yoakim, M, Schaffhausen, B, White, M F
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC50336/
https://ncbi.nlm.nih.gov/pubmed/1332046
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