Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3

Digestive organ expansion factor (Def) is a nucleolar protein that plays dual functions: it serves as a component of the ribosomal small subunit processome for the biogenesis of ribosomes and also mediates p53 degradation through the cysteine proteinase calpain-3 (CAPN3). However, nothing is known a...

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Vydáno v:PLoS Biol
Hlavní autoři: Guan, Yihong, Huang, Delai, Chen, Feng, Gao, Ce, Tao, Ting, Shi, Hui, Zhao, Shuyi, Liao, Zuyuan, Lo, Li Jan, Wang, Yingchun, Chen, Jun, Peng, Jinrong
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033581/
https://ncbi.nlm.nih.gov/pubmed/27657329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002555
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