Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli.

Newly synthesized proteins aggregate extensively in Escherichia coli rpoH mutants, which are deficient in the heat shock proteins (hsp). Overproduction of either GroEL and GroES or DnaK and DnaJ prevents aggregation. If expressed together, the four hsp are effective at physiological concentrations....

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Main Authors: Gragerov, A, Nudler, E, Komissarova, N, Gaitanaris, G A, Gottesman, M E, Nikiforov, V
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC50334/
https://ncbi.nlm.nih.gov/pubmed/1359538
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