Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation

BACKGROUND: Exacerbations of asthma are linked to significant decline in lung function and are often poorly controlled by corticosteroid treatment. Clinical investigations indicate that viral and bacterial infections play crucial roles in the onset of steroid-resistant inflammation and airways hyper...

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Udgivet i:PLoS One
Main Authors: Nguyen, Thi Hiep, Maltby, Steven, Eyers, Fiona, Foster, Paul S., Yang, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033241/
https://ncbi.nlm.nih.gov/pubmed/27657907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163392
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