Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications

OBJECTIVE: Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D in rheumatoid arthritis (RA). METHODS: Soluble Sema4D (sSema4D) levels in serum and synovial fluid were...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Yoshida, Yuji, Ogata, Atsushi, Kang, Sujin, Ebina, Kousuke, Shi, Kenrin, Nojima, Satoshi, Kimura, Tetsuya, Ito, Daisuke, Morimoto, Keiko, Nishide, Masayuki, Hosokawa, Takashi, Hirano, Toru, Shima, Yoshihito, Narazaki, Masashi, Tsuboi, Hideki, Saeki, Yukihiko, Tomita, Tetsuya, Tanaka, Toshio, Kumanogoh, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Rheumatoid Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032998/
https://ncbi.nlm.nih.gov/pubmed/25707877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39086
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