IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin lesions. We show that application of antigen to mouse skin su...

詳細記述

保存先:
書誌詳細
出版年:J Exp Med
主要な著者: Yoon, Juhan, Leyva-Castillo, Juan Manuel, Wang, Guoxing, Galand, Claire, Oyoshi, Michiko K., Kumar, Lalit, Hoff, Sabine, He, Rui, Chervonsky, Alexander, Oppenheim, Joost J., Kuchroo, Vijay K., van den Brink, Marcel R.M., Malefyt, Rene De Waal, Tessier, Philippe A., Fuhlbrigge, Robert, Rosenstiel, Philip, Terhorst, Cox, Murphy, George, Geha, Raif S.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2016
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032726/
https://ncbi.nlm.nih.gov/pubmed/27551155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150376
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