Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

The cell surface proteoglycan syndecan 1 (SDC1) is overexpressed in the malignant breast stromal fibroblasts, creating a favorable milieu for tumor cell growth. In the present study, we found that ionizing radiation, a well-established treatment in human breast cancer, provokes premature senescence...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Liakou, Eleni, Mavrogonatou, Eleni, Pratsinis, Harris, Rizou, Sophia, Evangelou, Konstantinos, Panagiotou, Petros N., Karamanos, Nikos K., Gorgoulis, Vassilis G., Kletsas, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032688/
https://ncbi.nlm.nih.gov/pubmed/27434331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100989
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