Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma

The challenges to effective drug delivery to brain tumors are twofold: (1) there is a lack of non-invasive methods of local delivery and (2) the blood-brain barrier limits systemic delivery. Intranasal delivery of therapeutics to the brain overcomes both challenges. In mouse model of malignant gliom...

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Publié dans:Stem Cell Reports
Auteurs principaux: Dey, Mahua, Yu, Dou, Kanojia, Deepak, Li, Gina, Sukhanova, Madina, Spencer, Drew A., Pituch, Katatzyna C., Zhang, Lingjiao, Han, Yu, Ahmed, Atique U., Aboody, Karen S., Lesniak, Maciej S., Balyasnikova, Irina V.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032402/
https://ncbi.nlm.nih.gov/pubmed/27594591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.07.024
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