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Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis

[Image: see text] Vaccines based on molecular subunit antigens are increasingly being investigated due to their improved safety and more precise targeting compared to classical whole-pathogen vaccines. However, subunit vaccines are inherently less immunogenic; thus, coadministration of an adjuvant t...

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Veröffentlicht in:Acc Chem Res
Hauptverfasser: Fernández-Tejada, Alberto, Tan, Derek S., Gin, David Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032057/
https://ncbi.nlm.nih.gov/pubmed/27568877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.accounts.6b00242
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