Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

Proprotein convertase subtilisin kexin 9 (PCSK9) is a key regulator of low-density lipoprotein receptor levels and LDL-cholesterol levels. Loss-of-function mutations in PCSK9 gene are associated with hypocholesterolaemia and protection against cardiovascular disease, identifying PCSK9 inhibition as...

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Sparad:
Bibliografiska uppgifter
I publikationen:Cardiovasc Res
Huvudupphovsmän: Norata, Giuseppe Danilo, Tavori, Hagai, Pirillo, Angela, Fazio, Sergio, Catapano, Alberico L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2016
Ämnen:
Review
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031950/
https://ncbi.nlm.nih.gov/pubmed/27496869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw194
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